Take the M40 into central London and exit just before the flyover following sign to the West End. At the lights turn right into Edgeware Road. At the second set of lights turn right into Sussex Gardens and follow this through a further two sets of lights. Talbot Square is a right turn immediately after crossing London Street. From Paddington Station (closest to the hotel) exit in Pread Street, walk down London Street into Sussex Gardens and turn into Talbot Square (first right into the square, 3 minutes walking distance from the station).
For directions from a nearby airport, click on one of the links below: